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GlyT1 Inhibitor 1

Product Specifications

UNSPSC Description

GlyT1 Inhibitor 1 is a potent and selective GlyT1 inhibitor with an IC50 of 38 nM for rGlyT1[1]. Antipsychotic activity[1].

Target Antigen

GlyT

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel;Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/GlyT1_Inhibitor_1.html

Purity

98.59

Solubility

DMSO : 25 mg/mL (ultrasonic;warming;heat to 60°C)

Smiles

CC(C)OC1=C(C(N2CC3=CN(C4=CC(C)=NC=C4)N=C3C2)=O)C=C(C#N)C=C1

Molecular Weight

387.43

References & Citations

[1]Santora VJ, et al. Design and Synthesis of Novel and Selective Glycine Transporter-1 (GlyT1) Inhibitors with Memory Enhancing Properties. J Med Chem. 2018 Jul 26;61(14):6018-6033.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-112432/GlyT1-Inhibitor-1-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-112432/GlyT1-Inhibitor-1-SDS-MedChemExpress.pdf

Clinical Information

No Development Reported

CAS Number

1820934-93-7

Available Sizes

Curated Selection

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