GlyT1 Inhibitor 1
GlyT1 Inhibitor 1 is a potent and selective GlyT1 inhibitor with an IC50 of 38 nM for rGlyT1[1]. Antipsychotic activity[1].
Product Specifications
CAS Number
[1820934-93-7]
UNSPSC
12352005
Target
GlyT
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/GlyT1_Inhibitor_1.html
Purity
98.59
Solubility
DMSO : 25 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
CC(C)OC1=C(C(N2CC3=CN(C4=CC(C)=NC=C4)N=C3C2)=O)C=C(C#N)C=C1
Molecular Formula
C22H21N5O2
Molecular Weight
387.43
References & Citations
[1]Santora VJ, et al. Design and Synthesis of Novel and Selective Glycine Transporter-1 (GlyT1) Inhibitors with Memory Enhancing Properties. J Med Chem. 2018 Jul 26;61 (14) :6018-6033.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
GlyT1
Available Sizes
Curated Selection
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