1H-pyrazole

1H-pyrazole is a nitrogen-containing heterocyclic compound composed of a five-membered ring and two nitrogen atoms. 1H-pyrazole is an intermediate in organic synthesis. 1H-pyrazole coordinates with metal ions. 1H-pyrazole derivatives have antibacterial, anti-inflammatory, anti-malarial, and anti-leishmanial activities[1][2][3][4].

Product Specifications

CAS Number

[288-13-1]

Product Name Alternative

Pyrazole

UNSPSC

12352005

Hazard Statement

H302, H311, H315, H318, H373, H412

Target

Biochemical Assay Reagents; Drug Intermediate

Type

Natural Products

Related Pathways

Others

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Infection; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/1h-pyrazole.html

Purity

99.98

Solubility

DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

N1=CC=CN1

Molecular Formula

C3H4N2

Molecular Weight

68.08

Precautions

H302, H311, H315, H318, H373, H412

References & Citations

[1]Bekhit AA, et al. Synthesis and biological evaluation of some thiazolyl and thiadiazolyl derivatives of 1H-pyrazole as anti-inflammatory antimicrobial agents. Eur J Med Chem. 2008 Mar;43 (3) :456-63.|[2]Vyas KM, et al. Synthesis, spectroscopic characterization and DNA nuclease activity of Cu (II) complexes derived from pyrazolone based NSO-donor Schiff base ligands. Spectrochim Acta A Mol Biomol Spectrosc. 2011 Dec 15;84 (1) :256-68.|[3]Jhuang J Y, et al. Adsorption and reaction pathways of 1H-pyrazole on Cu (100) and O/Cu (100) . The Journal of Physical Chemistry C, 2018, 122 (11) : 6195-6208.|[4]Bekhit AA, et al. Evaluation of some 1H-pyrazole derivatives as a dual acting antimalarial and anti-leishmanial agents. Pak J Pharm Sci. 2014 Nov;27 (6) :1767-73. PMID: 25362601.