7,3',4'-Tri-O-methylluteolin

7,3',4'-Tri-O-methylluteolin (5-Hydroxy-3',4',7-trimethoxyflavone) is a flavonoid with multiple biological activities. 7,3',4'-Tri-O-methylluteolin inhibits soybean lipoxygenase (LOX), with an IC50 value of 23.97 µg/mL. 7,3',4'-Tri-O-methylluteolin possesses anti-inflammatory effects in Lipopolysaccharides (HY-D1056) (LPS) -induced RAW 264.7 macrophages. 7,3',4'-Tri-O-methylluteolin inhibits the binding of MDM2 with p53 and induces apoptosis in MCF-7 breast cancer cells. 7,3',4'-Tri-O-methylluteolin also has antioxidant, antifungal and antitrypanosomal activities[1][2][3]sup>[4]sup>[5].

Product Specifications

CAS Number

[29080-58-8]

Product Name Alternative

5-Hydroxy-3',4',7-trimethoxyflavone

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; COX; Fungal; Interleukin Related; Lipoxygenase; Parasite; TNF Receptor

Type

Natural Products

Related Pathways

Anti-infection; Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Cancer; Infection; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/7-3-4-tri-o-methylluteolin.html

Purity

99.28

Solubility

DMSO : 20 mg/mL (ultrasonic)

Smiles

OC1=C2C(OC(C3=CC=C(OC)C(OC)=C3)=CC2=O)=CC(OC)=C1

Molecular Formula

C18H16O6

Molecular Weight

328.32

Precautions

H302, H315, H319, H335

References & Citations

[1]Sudha, A, et al. Protective effect of 5-hydroxy-3′,4′,7-trimethoxyflavone against inflammation induced by lipopolysaccharide in RAW 264.7 macrophage: in vitro study and in silico validation. Medicinal Chemistry Research, 2016,25 (9), 1754–1767.|[2]Sudha A, et al. In vitro, fluorescence-quenching and computational studies on the interaction between lipoxygenase and 5-hydroxy-3',4',7-trimethoxyflavone from Lippia nodiflora L. J Recept Signal Transduct Res. 2015;35 (6) :569-77.|[3]Sudha A, et al. Antiproliferative and apoptosis-induction studies of 5-hydroxy 3',4',7-trimethoxyflavone in human breast cancer cells MCF-7: an in vitro and in silico approach. J Recept Signal Transduct Res. 2018 Jun;38 (3) :179-190.|[4]G. S. Çitoğlu, et al. Antifungal Flavonoids from Ballota glandulosissima. Pharmaceutical Biology. September 200841 (7) :483-486.|[5]Kamal, Nurkhalida, et al. Anti-infective activities of secondary metabolites from Vitex pinnata. Journal of Applied Pharmaceutical Science, 2016, 6 (1) . pp. 102-106. ISSN 2231-3354.