Corynoxeine

Corynoxeine, isolated from the hook of Uncaria rhynchophylla, is a potent ERK1/ERK2 inhibitor of key PDGF-BB-induced vascular smooth muscle cells (VSMCs) proliferation.

Product Specifications

CAS Number

[630-94-4]

UNSPSC

12352005

Target

ERK

Type

Natural Products

Related Pathways

MAPK/ERK Pathway; Stem Cell/Wnt

Applications

COVID-19-immunoregulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/Corynoxeine.html

Purity

99.97

Solubility

DMSO : ≥ 3.8 mg/mL

Smiles

O=C(NC1=C2C=CC=C1)[C@]32[C@@](C[C@H](/C(C(OC)=O)=C\OC)[C@@H](C=C)C4)([H])N4CC3

Molecular Formula

C22H26N2O4

Molecular Weight

382.45

References & Citations

[1]Kim TJ, et al. Corynoxeine isolated from the hook of Uncaria rhynchophylla inhibits rat aortic vascular smooth muscle cell proliferation through the blocking of extracellular signal regulated kinase 1/2 phosphorylation. Biol Pharm Bull. 2008 Nov;31 (11) :2073-8.