Thiochrome
Thiochrome, a natural oxidation product and metabolite of thiamine, is a selective M4 muscarinic receptor of acetylcholine (ACh) affinity enhancer. Thiochrome has neutral cooperativity with ACh at M1 to M3 receptors[1][2].
Product Specifications
CAS Number
92-35-3
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
MAChR
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/thiochrome.html
Concentration
10mM
Purity
99.0
Solubility
DMSO : 25 mg/mL (ultrasonic)
Smiles
OCCC1=C(C)N2CC3=CN=C(C)N=C3N=C2S1
Molecular Formula
C12H14N4OS
Molecular Weight
262.33
Precautions
H315, H319, H335
References & Citations
[1]Petrov SA, et al. Administration of Thiamine and Thiochrome Enhanced Reproduction of Chlorella, Drosophila melanogaster, and Danio. J Nutr Sci Vitaminol (Tokyo) . 2016;62 (1) :6-11.|[2]Lazareno S, et al. Thiochrome enhances acetylcholine affinity at muscarinic M4 receptors: receptor subtype selectivity via cooperativity rather than affinity. Mol Pharmacol. 2004 Jan;65 (1) :257-66.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MAChR3; mAChR4
Available Sizes
Frequently Asked Questions
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