Thiochrome

Thiochrome, a natural oxidation product and metabolite of thiamine, is a selective M4 muscarinic receptor of acetylcholine (ACh) affinity enhancer. Thiochrome has neutral cooperativity with ACh at M1 to M3 receptors[1][2].

Product Specifications

CAS Number

[92-35-3]

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

MAChR

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/thiochrome.html

Concentration

10mM

Purity

99.0

Solubility

DMSO : 25 mg/mL (ultrasonic)

Smiles

OCCC1=C(C)N2CC3=CN=C(C)N=C3N=C2S1

Molecular Formula

C12H14N4OS

Molecular Weight

262.33

Precautions

H315, H319, H335

References & Citations

[1]Petrov SA, et al. Administration of Thiamine and Thiochrome Enhanced Reproduction of Chlorella, Drosophila melanogaster, and Danio. J Nutr Sci Vitaminol (Tokyo) . 2016;62 (1) :6-11.|[2]Lazareno S, et al. Thiochrome enhances acetylcholine affinity at muscarinic M4 receptors: receptor subtype selectivity via cooperativity rather than affinity. Mol Pharmacol. 2004 Jan;65 (1) :257-66.