Hydroxocobalamin (acetate)

Hydroxocobalamin acetate is an injectable natural vitamin B12. Hydroxocobalamin acetate binds to NO. Hydroxocobalamin acetate detoxifies Cyanide and NaSH. Hydroxocobalamin acetate reduces hypotension. Hydroxocobalamin acetate is used in research related to vitamin B12 deficiency, including pernicious anemia[1][2][3][4][5][6][7][8].

Product Specifications

CAS Number

[22465-48-1]

Product Name Alternative

Vitamin B12a (acetate)

UNSPSC

12352005

Hazard Statement

H351

Target

NO Synthase

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/hydroxocobalamin-acetate.html

Purity

98.0

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

C[C@@]12[N]([Co+3]34([N]5=C[N@@]([C@@H](O[C@H](CO)[C@H]6OP7([O-])=O)[C@@H]6O)C8=C5C=C(C)C(C)=C8)([O-]C(C)=O)[N-]9C2[C@H](CC(N)=O)[C@@](C)(CCC(NC[C@H](C)O7)=O)C9=C(C)C([C@@H](CCC(N)=O)C%10(C)C)=[N]3C%10=CC%11=[N]4C([C@](CC(N)=O)(C)[C@@H]%11CCC(N)=O)=C%12C)=C%12[C@@H](CCC(N)=O)[C@]1(C)CC(N)=O

Molecular Formula

C64H91CoN13O16P

Molecular Weight

1388.39

Precautions

H351

References & Citations

[1]Cheungpasitporn W, et al. High-dose hydroxocobalamin for vasoplegic syndrome causing false blood leak alarm. Clin Kidney J. 2017 Jun;10 (3) :357-362.|[2]Wang H, et al. Oral vitamin B12 versus intramuscular vitamin B12 for vitamin B12 deficiency. Cochrane Database Syst Rev. 2018 Mar 15;3:CD004655.|[3]Greenberg SS, et al. Hydroxocobalamin (vitamin B12a) prevents and reverses endotoxin-induced hypotension and mortality in rodents: role of nitric oxide. J Pharmacol Exp Ther. 1995 Apr;273 (1) :257-65.|[4]Owiredu S, et al. In vitro comparison of hydroxocobalamin (B12a) and the mitochondrial directed therapy by a succinate prodrug in a cellular model of cyanide poisoning. Toxicol Rep. 2020 Sep 17;7:1263-1271.|[5]Greenberg SS, et al. Hydroxocobalamin (vitamin B12a) prevents and reverses endotoxin-induced hypotension and mortality in rodents: role of nitric oxide. J Pharmacol Exp Ther. 1995 Apr;273 (1) :257-65. |[6]Oyewole O I, et al. Hydroxocobalamin (vit b12a) effectively reduced extent of cyanide poisoning arising from oral amygdalin ingestion in rats[J]. J. Toxicol. Environ. Health Sci, 2009, 1 (1) : 8-11. |[7]Borron SW, et al. Efficacy of hydroxocobalamin for the treatment of acute cyanide poisoning in adult beagle dogs. Clin Toxicol (Phila) . 2006;44 Suppl 1:5-15.|[8]Truong DH, et al. Prevention of hydrogen sulfide (H2S) -induced mouse lethality and cytotoxicity by hydroxocobalamin (vitamin B (12a) ) . Toxicology. 2007 Dec 5;242 (1-3) :16-22.