Lumiflavin

Lumiflavin (Lumiflavine), a riboflavine analog, causes significant inhibition of riboflavine uptake. Lumiflavin can effectively reduce the riboflavin enrichment in cancer stem-like cells (CSCs) and sensitize the effect of cisplatin Diamminedichloroplatinum (DDP) on CSCs. Lumiflavin is promising for research of ovarian cancer[1][2][3].

Product Specifications

CAS Number

[1088-56-8]

Product Name Alternative

Lumiflavine

UNSPSC

12171500

Hazard Statement

H302

Target

Fluorescent Dye; Notch

Type

Dye Reagents

Related Pathways

Neuronal Signaling; Others; Stem Cell/Wnt

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/lumiflavin.html

Purity

99.79

Solubility

0.1 M NaOH : 10 mg/mL (ultrasonic)

Smiles

CC1=CC2=C(N(C(C3=N2)=NC(NC3=O)=O)C)C=C1C

Molecular Formula

C13H12N4O2

Molecular Weight

256.26

Precautions

H302

References & Citations

[1]H M Said, et al. Mechanism of riboflavine uptake by Caco-2 human intestinal epithelial cells. Am J Physiol. 1994 Jan;266 (1 Pt 1) :G15-21.|[2]Yang R, et al. Lumiflavin increases the sensitivity of ovarian cancer stem-like cells to cisplatin by interfering with riboflavin. J Cell Mol Med. 2019 Aug;23 (8) :5329-5339. |[3]Yang R, et al. Lumiflavin Reduces Cisplatin Resistance in Cancer Stem-Like Cells of OVCAR-3 Cell Line by Inducing Differentiation. Front Oncol. 2022 May 20;12:859275.