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FRM-024

FRM-024 is a potent CNS-penetrant gamma secretase modulator for familial Alzheimer’s disease.

Product Specifications

CAS Number

2085780-87-4

UNSPSC

12352005

Target

γ-secretase

Type

Reference compound

Related Pathways

Neuronal Signaling; Stem Cell/Wnt

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/frm-024.html

Purity

99.45

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

ClC1=CC=C(C=C1)[C@H]2[C@@H](C3CC3)ON=C(C4=CC=C(N5C=C(N=C5)C)C(OC)=N4)N2

Molecular Formula

C22H22ClN5O2

Molecular Weight

423.90

References & Citations

[1]Bursavich MG, et al. Discovery of the Oxadiazine FRM-024: A Potent CNS-Penetrant Gamma Secretase Modulator. J Med Chem. 2021 Oct 14;64 (19) :14426-14447.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, protect from light, stored under nitrogen)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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