FRM-024
FRM-024 is a potent CNS-penetrant gamma secretase modulator for familial Alzheimer’s disease.
Product Specifications
CAS Number
2085780-87-4
UNSPSC
12352005
Target
γ-secretase
Type
Reference compound
Related Pathways
Neuronal Signaling; Stem Cell/Wnt
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/frm-024.html
Purity
99.45
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
ClC1=CC=C(C=C1)[C@H]2[C@@H](C3CC3)ON=C(C4=CC=C(N5C=C(N=C5)C)C(OC)=N4)N2
Molecular Formula
C22H22ClN5O2
Molecular Weight
423.90
References & Citations
[1]Bursavich MG, et al. Discovery of the Oxadiazine FRM-024: A Potent CNS-Penetrant Gamma Secretase Modulator. J Med Chem. 2021 Oct 14;64 (19) :14426-14447.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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