Mevalonic acid

Mevalonic acid (MVA) is a precursor substance of the mevalonate pathway, which is essential for cell growth and proliferation. Mevalonic acid is effective in inhibiting Simvastatin (HY-17502) -induced decrease in C2C12 cell viability in vitro. Mevalonic acid can be used in studies of myopathy and heart failure[1][2].

Product Specifications

CAS Number

[150-97-0]

Product Name Alternative

MVA

UNSPSC

12352211

Hazard Statement

H302, H312, H332

Target

Endogenous Metabolite

Type

Natural Products

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Metabolic Disease; Neurological Disease; Cardiovascular Disease; Cancer

Assay Protocol

https://www.medchemexpress.com/Mevalonic_acid.html

Purity

99.0

Solubility

10 mM in DMSO

Smiles

O=C(O)CC(C)(O)CCO

Molecular Formula

C6H12O4

Molecular Weight

148.16

Precautions

H302, H312, H332

References & Citations

[1]Moschetti A, et al. Coenzyme Q nanodisks counteract the effect of statins on C2C12 myotubes. Nanomedicine. 2021 Oct;37:102439. |[2]Soma MR, et al. Cholesterol and mevalonic acid modulation in cell metabolism and multiplication. Toxicol Lett. 1992 Dec;64-65 Spec No:1-15.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Natural Products

Clinical Information

Phase 3

Citation 01

Biochem Biophys Res Commun. 2020 Feb 19;522 (4) :862-868.|Biomedicines. 2022 Oct 5;10 (10) :2489.|Drugs R D. 2023 Dec;23 (4) :439-451.|Acta Pharm Sin B. 2023 Jun;13 (6) :2585-2600.|Acta Pharmacol Sin. 2021 Nov;42 (11) :1875-1887.|Biochim Biophys Acta Mol Cell Biol Lipids. 2022 Dec;1867 (12) :159217.|Cell Biosci. 2021 Oct 9;11 (1) :179.|Life Sci Alliance. 2022 Jan 4;5 (3) :e202101256.|Nature. 2025 Jul;643 (8070) :192-200.