CTSL/CAPN1-IN-2

CTSL/CAPN1-IN-2 (Compound 14b) is an orally active inhibitor of both CTSL and CAPN1, with IC50 values of 6.88 nM and 347.6 nM, respectively. CTSL/CAPN1-IN-2 possesses anti-inflammatory properties and favorable pharmacokinetic characteristics. CTSL/CAPN1-IN-2 exhibits broad-spectrum antiviral activity against coronaviruses by blocking viral entry[1].

Product Specifications

CAS Number

[2410075-64-6]

UNSPSC

12352005

Target

Cathepsin; SARS-CoV

Type

Reference compound

Related Pathways

Anti-infection; Metabolic Enzyme/Protease

Applications

COVID-19-anti-virus

Field of Research

Infection; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/ctsl-capn1-in-2.html

Solubility

10 mM in DMSO

Smiles

O=C(C1=CC2=CC=CC=C2O1)N[C@@H](CC3CCCCC3)C(N[C@H](C(C(NCC4=CC=CC=C4)=O)=O)C[C@H]5C(NCCC5)=O)=O

Molecular Formula

C34H40N4O6

Molecular Weight

600.70

References & Citations

[1]Xie X, et al. Structure-based design of pan-coronavirus inhibitors targeting host cathepsin L and calpain-1. Signal Transduct Target Ther. 2024 Mar 6;9 (1) :54.