Diphenylamine hydrochloride

Diphenylamine hydrochloride (N-Phenylaniline hydrochloride) is an antihyperglycemic agent with oral activity and a common structure in non-steroidal anti-inflammatory drugs (NSAIDs) that uncouples oxidative phosphorylation in mitochondria, leading to a decrease in hepatic cell ATP levels and causing liver cell damage. Diphenylamine hydrochloride is also an industrial antioxidant, a dyeing mordant, and is used in agriculture as an antifungal and antibacterial agent[1][2][3][4].

Product Specifications

CAS Number

[537-67-7]

Product Name Alternative

N-Phenylaniline hydrochloride

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Bacterial; Fungal

Type

Natural Products

Related Pathways

Anti-infection

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/diphenylamine-hydrochloride.html

Purity

99.96

Solubility

DMSO : 250 mg/mL (ultrasonic)

Smiles

[H]Cl.C1(NC2=CC=CC=C2)=CC=CC=C1

Molecular Formula

C12H12ClN

Molecular Weight

205.69

Precautions

H302, H315, H319, H335

References & Citations

[1]Safe S, et al. Identification of toxic impurities in commercial diphenylamine. Bull Environ Contam Toxicol. 1977 Feb;17 (2) :204-7.|[2]Masubuchi Y, et al. Possible mechanism of hepatocyte injury induced by diphenylamine and its structurally related nonsteroidal anti-inflammatory drugs. J Pharmacol Exp Ther. 2000 Mar;292 (3) :982-7.|[3]W E Alexander, et al. Metabolism of diphenylamine in the rat, rabbit and man. Food Cosmet Toxicol. 1965 Oct;3 (4) :571-9. |[4]M S Karawya, wt al. Diphenylamine, an antihyperglycemic agent from onion and tea. J Nat Prod. 1984 Sep-Oct;47 (5) :775-80.