PTP1B-IN-4

PTP1B-IN-4 is a non-competitive allosteric inhibitor of the protein tyrosine phosphatase PTP1B, with an IC50 of 8 μM. PTP1B-IN-4 is potentail for the research of obesity and diabetes[1][2].

Product Specifications

CAS Number

[765317-72-4]

UNSPSC

12352005

Target

Phosphatase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/ptp1b-in-4.html

Purity

99.81

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=S(C1=CC=C2C(C(C3=CC(Br)=C(O)C(Br)=C3)=O)=C(CC)OC2=C1)(NC4=CC=C(S(=O)(NC5=NC=CS5)=O)C=C4)=O

Molecular Formula

C26H19Br2N3O7S3

Molecular Weight

741.45

References & Citations

[1]Wiesmann, C., et al. Allosteric inhibition of protein tyrosine phosphatase 1B. Nature Structural & Molecular Biology, 2004. 11 (8), 730–737.|[2]Jin, T., et al. Selective binding modes and allosteric inhibitory effects of lupane triterpenes on protein tyrosine phosphatase 1B. Scientific Reports, 2016. 6 (1) .