Cyclo (Arg-Gly-Asp-D-Phe-Cys)

Cyclo (Arg-Gly-Asp-D-Phe-Cys) (Cyclo RGDfC), a cyclic RGD peptide which has high affinity to αvβ3, can disrupt cell integrin interactions. Cyclo (Arg-Gly-Asp-D-Phe-Cys) inhibits pluripotent marker expression in embryonic stem cells (ESCs) and the tumorigenic potential of mESCs in vivo. Cyclo (Arg-Gly-Asp-D-Phe-Cys) can be used in the research of tumors[1].

Product Specifications

CAS Number

[862772-11-0]

Product Name Alternative

Cyclo (RGDfC)

UNSPSC

12352209

Hazard Statement

H302, H315, H319

Target

Integrin

Type

Peptides

Related Pathways

Cytoskeleton

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/cyclo-arg-gly-asp-d-phe-cys.html

Purity

98.45

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C([C@@H](CC1=CC=CC=C1)NC([C@H](CC(O)=O)NC(CNC2=O)=O)=O)N[C@@H](CS)C(N[C@H]2CCCNC(N)=N)=O

Molecular Formula

C24H34N8O7S

Molecular Weight

578.64

Precautions

H302, H315, H319

References & Citations

[1]Hazenbiller O, et al. Reduction of pluripotent gene expression in murine embryonic stem cells exposed to mechanical loading or Cyclo RGD peptide. BMC Cell Biol. 2017 Nov 14;18 (1) :32.