IACS-15414
IACS-15414 is a potent and orally bioavailable SHP2 inhibitor with an IC50 value of 122 nM.
Product Specifications
CAS Number
2411321-29-2
UNSPSC
12352005
Target
Phosphatase; SHP2
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease; Protein Tyrosine Kinase/RTK
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/iacs-15414.html
Purity
99.39
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
ClC1=CC=CC(N2C(C)=NC(N3CCC4([C@H](N)[C@H](C)OC4)CC3)=CC2=O)=C1Cl
Molecular Formula
C20H24Cl2N4O2
Molecular Weight
423.34
References & Citations
[1]Czako B, et al. Discovery of 6-[ (3S,4S) -4-Amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl]-3- (2,3-dichlorophenyl) -2-methyl-3,4-dihydropyrimidin-4-one (IACS-15414), a Potent and Orally Bioavailable SHP2 Inhibitor. J Med Chem. 2021 Oct 28;64 (20) :15141-15169.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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