PDE5-IN-7

PDE5-IN-7 (compound 8) is a selective phosphodiesterase 5 (PDE 5) inhibitor with an IC50 value of 5 nM, while an IC50 of 300 nM for PDE 1[1].

Product Specifications

CAS Number

[139756-21-1]

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Phosphodiesterase (PDE)

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/pde5-in-7.html

Purity

99.83

Solubility

DMSO : 33.33 mg/mL (ultrasonic)

Smiles

O=C1C(N(C)N=C2CCC)=C2N=C(C3=CC=CC=C3OCC)N1

Molecular Formula

C17H20N4O2

Molecular Weight

312.37

Precautions

H315, H319, H335

References & Citations

[1]Haning H, et al. Imidazo[5,1-f]triazin-4 (3H) -ones, a new class of potent PDE 5 inhibitors. Bioorg Med Chem Lett. 2002 Mar 25;12 (6) :865-8. |[2]Assemat G, et al. Isolation and identification of ten new sildenafil derivatives in an alleged herbal supplement for sexual enhancement. J Pharm Biomed Anal. 2020 Nov 30;191:113482.