Acrizanib
Acrizanib (LHA510) is a VEGFR-2 inhibitor, with an IC50 of 17.4 nM for BaF3-VEGFR-2[1].
Product Specifications
CAS Number
1229453-99-9
Product Name Alternative
LHA510
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
VEGFR
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/Acrizanib.html
Purity
99.84
Solubility
DMSO : 41.67 mg/mL (ultrasonic)
Smiles
O=C(N1C2=CC=C(OC3=NC=NC(CNC)=C3)C=C2C=C1)NC4=NN(C)C(C(F)(F)F)=C4
Molecular Formula
C20H18F3N7O2
Molecular Weight
445.40
Precautions
H302, H315, H319, H335
References & Citations
[1]Adams CM, et al. The Discovery of N- (1-Methyl-5- (trifluoromethyl) -1H-pyrazol-3-yl) -5- ((6- ((methylamino) methyl) pyrimidin-4-yl) oxy) -1H-indole-1-carboxamide (Acrizanib), a VEGFR-2 Inhibitor Specifically Designed for Topical Ocular Delivery, as a Therapy for Neovascular Age-Related Macular Degeneration. J Med Chem. 2018 Feb 22;61 (4) :1622-1635.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
VEGFR2/KDR/Flk-1
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
BNC470012-500 1x 500 µL
Tyrosinase (T311), CF647 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC401531-100 1x 100 µL
IL3RA / CD123 (Acute Myeloid Leukemia Marker) (IL3RA/1531), CF640R conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC040201-100 1x 100 µL
CD2 / Lymphocyte Function Antigen 2 (LFA-2) (UMCD2), CF405S conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC940872-500 1x 500 µL
Retinol Binding Protein-1 (RBP/872), CF594 conjugate, 0.1mg/mL
Sign In for Pricing
View Details