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MUT056399

MUT056399 (Fab-001) is a highly potent inhibitor of the FabI enzyme of both S. aureus and E. coli with 50% inhibitory concentration IC50s of 12 nM and 58 nM, respectively.

Product Specifications

CAS Number

1269055-85-7

Product Name Alternative

Fab-001

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Bacterial

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/MUT056399.html

Concentration

10mM

Purity

99.87

Solubility

DMSO : ≥ 31 mg/mL

Smiles

CCC1=CC(O)=C(OC2=CC=C(C(N)=O)C=C2F)C=C1F

Molecular Formula

C15H13F2NO3

Molecular Weight

293.27

Precautions

H302, H315, H319, H335

References & Citations

[1]Escaich S, et al. The MUT056399 inhibitor of FabI is a new antistaphylococcal compound. Antimicrob Agents Chemother. 2011 Oct;55 (10) :4692-7.|[2]Schiebel J, et al. An ordered water channel in Staphylococcus aureus FabI: unraveling the mechanism of substrate recognitionand reduction. Biochemistry. 2015 Mar 17;54 (10) :1943-55.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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