MUT056399
MUT056399 (Fab-001) is a highly potent inhibitor of the FabI enzyme of both S. aureus and E. coli with 50% inhibitory concentration IC50s of 12 nM and 58 nM, respectively.
Product Specifications
CAS Number
1269055-85-7
Product Name Alternative
Fab-001
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Bacterial
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/MUT056399.html
Concentration
10mM
Purity
99.87
Solubility
DMSO : ≥ 31 mg/mL
Smiles
CCC1=CC(O)=C(OC2=CC=C(C(N)=O)C=C2F)C=C1F
Molecular Formula
C15H13F2NO3
Molecular Weight
293.27
Precautions
H302, H315, H319, H335
References & Citations
[1]Escaich S, et al. The MUT056399 inhibitor of FabI is a new antistaphylococcal compound. Antimicrob Agents Chemother. 2011 Oct;55 (10) :4692-7.|[2]Schiebel J, et al. An ordered water channel in Staphylococcus aureus FabI: unraveling the mechanism of substrate recognitionand reduction. Biochemistry. 2015 Mar 17;54 (10) :1943-55.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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