N-Boc-dolaproine-OH (dicyclohexylamine)

N-Boc-dolaproine-OH dicyclohexylamine is the amino acid residue of the pentapeptide Dolastatin 10 (HY-15580) . Dolastatin 10 inhibits tubulin polymerization and mitosis and has anticancer activity[1].

Product Specifications

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Microtubule/Tubulin; Mitosis

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Cytoskeleton

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/n-boc-dolaproine-oh-dicyclohexylamine.html

Purity

96.59

Solubility

10 mM in DMSO

Smiles

O[C@H]([C@@H](C)C(O)=O)[C@H]1N(C(OC(C)(C)C)=O)CCC1.C2(NC3CCCCC3)CCCCC2

Molecular Formula

C25H46N2O5

Molecular Weight

454.64

Precautions

H302, H315, H319, H335

References & Citations

[1]Almeida W P, et al. An easy and stereoselective synthesis of N-Boc-dolaproine via the Baylis–Hillman reaction[J]. Tetrahedron letters, 2003, 44 (5) : 937-940.