Glycodeoxycholic acid

Glycodeoxycholic Acid is a natural product found in Streptomyces nigricans, Trypanosoma brucei and C. elegans. Glycodeoxycholic Acid induces hepatocyte necrosis and autophagy in patients with obstructive cholestasis[1][2][3].

Product Specifications

CAS Number

[360-65-6]

UNSPSC

12352211

Hazard Statement

H315, H319, H335

Target

Autophagy; Endogenous Metabolite; STAT

Type

Natural Products

Related Pathways

Autophagy; JAK/STAT Signaling; Metabolic Enzyme/Protease; Stem Cell/Wnt

Applications

Neuroscience-Neuromodulation

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/glycodeoxycholic-acid.html

Concentration

10mM

Purity

99.91

Solubility

DMSO : 87.5 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

C[C@@H]([C@]1(CC[C@]2([C@@]3(CC[C@@]4(C[C@@H](CC[C@@]4([C@]3(C[C@@H]([C@@]21C)O)[H])C)O)[H])[H])[H])[H])CCC(NCC(O)=O)=O

Molecular Formula

C26H43NO5

Molecular Weight

449.62

Precautions

H315, H319, H335

References & Citations

[1]Shi C, et al. Glycochenodeoxycholic acid induces stemness and chemoresistance via the STAT3 signaling pathway in hepatocellular carcinoma cells. Aging (Albany NY) . 2020 Aug 3;12 (15) :15546-15555.|[2]Vaz AR, et al. Bilirubin selectively inhibits cytochrome c oxidase activity and induces apoptosis in immature cortical neurons: assessment of the protective effects of glycoursodeoxycholic acid. J Neurochem. 2010 Jan;112 (1) :56-65.|[3]Fauzi A, et al. Role of glycodeoxycholic acid to induce acute pancreatitis in Macaca nemestrina. J Med Primatol. 2022 Jun;51 (3) :134-142. doi: 10.1111/jmp.12577. Epub 2022 Mar 20. PMID: 35306662; PMCID: PMC9310849.