Thiamet G
Thiamet G is a potent and selective inhibitor of O-GlcNAcase (OGA), which acts to remove O-GlcNAc from modified proteins, with Ki of 20 nM for human OGA.
Product Specifications
CAS Number
1009816-48-1
UNSPSC
12352005
Hazard Statement
H317
Target
Autophagy; OGA
Type
Reference compound
Related Pathways
Autophagy; Neuronal Signaling
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Thiamet-G.html
Concentration
10mM
Purity
99.99
Solubility
DMSO : 233.33 mg/mL (ultrasonic) |H2O : ≥ 50 mg/mL
Smiles
O[C@H]1[C@H](O)[C@@]2([H])N=C(NCC)S[C@@]2([H])O[C@@H]1CO
Molecular Formula
C9H16N2O4S
Molecular Weight
248.30
Precautions
H317
References & Citations
[1]Yuzwa SA, et al. Increasing O-GlcNAc slows neurodegeneration and stabilizes tau against aggregation. Nat Chem Biol. 2012 Feb 26;8 (4) :393-9.|[2]Andrés-Bergós J, et al. The increase in O-linked N-acetylglucosamine protein modification stimulates chondrogenic differentiation both in vitro and in vivo. J Biol Chem. 2012 Sep 28;287 (40) :33615-28.|[3]Ding N, et al. Thiamet-G-mediated inhibition of O-GlcNAcase sensitizes human leukemia cells to microtubule-stabilizing agent NSC 125973. Biochem Biophys Res Commun. 2014 Oct 24;453 (3) :392-7.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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