Thiamet G

Thiamet G is a potent and selective inhibitor of O-GlcNAcase (OGA), which acts to remove O-GlcNAc from modified proteins, with Ki of 20 nM for human OGA.

Product Specifications

CAS Number

[1009816-48-1]

UNSPSC

12352005

Hazard Statement

H317

Target

Autophagy; OGA

Type

Reference compound

Related Pathways

Autophagy; Neuronal Signaling

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/Thiamet-G.html

Concentration

10mM

Purity

99.99

Solubility

DMSO : 233.33 mg/mL (ultrasonic) |H2O : ≥ 50 mg/mL

Smiles

O[C@H]1[C@H](O)[C@@]2([H])N=C(NCC)S[C@@]2([H])O[C@@H]1CO

Molecular Formula

C9H16N2O4S

Molecular Weight

248.30

Precautions

H317

References & Citations

[1]Yuzwa SA, et al. Increasing O-GlcNAc slows neurodegeneration and stabilizes tau against aggregation. Nat Chem Biol. 2012 Feb 26;8 (4) :393-9.|[2]Andrés-Bergós J, et al. The increase in O-linked N-acetylglucosamine protein modification stimulates chondrogenic differentiation both in vitro and in vivo. J Biol Chem. 2012 Sep 28;287 (40) :33615-28.|[3]Ding N, et al. Thiamet-G-mediated inhibition of O-GlcNAcase sensitizes human leukemia cells to microtubule-stabilizing agent NSC 125973. Biochem Biophys Res Commun. 2014 Oct 24;453 (3) :392-7.