FPR1 antagonist 1

FPR1 antagonist 1 (compound 24a) is a formyl peptide receptor 1 (FPR1) antagonist with an IC50 of 25 nM. FPR1 antagonist 1 inhibits cell growth through a combined effect on cell proliferation and apoptosis and reduces cell migration, while inducing an increase in angiogenesis[1].

Product Specifications

UNSPSC

12352005

Target

Apoptosis; Formyl Peptide Receptor (FPR)

Type

Reference compound

Related Pathways

Apoptosis; GPCR/G Protein

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/fpr1-antagonist-1.html

Purity

95.0

Solubility

DMSO : 200 mg/mL (ultrasonic)

Smiles

CC(OC1=CC2=C(C=C1CCCCCC)C(C(C3=CC=CC=C3OC)=C(C)O2)=O)=O

Molecular Formula

C25H28O5

Molecular Weight

408.49

References & Citations

[1]Fabio Francavilla, et al. Development of potent isoflavone-based formyl peptide receptor 1 (FPR1) antagonists and their effects in gastric cancer cell models. Eur J Med Chem. 2023 Oct 4:261:115854.