Gemcitabine elaidate (hydrochloride)

Gemcitabine elaidate (CP-4126) hydrochloride is lipophilic pro-agent of Gemcitabine. Gemcitabine elaidate hydrochloride is converted to Gemcitabine by esterases in order to be phosphorylated. Gemcitabine elaidate hydrochloride exhibits anti-tumor activity[1][2].

Product Specifications

CAS Number

[2918768-08-6]

Product Name Alternative

CP-4126 (hydrochloride) ; CO-101 (hydrochloride) ; Gemcitabine 5'-elaidate (hydrochloride)

UNSPSC

12352005

Target

Apoptosis; Autophagy; Nucleoside Antimetabolite/Analog

Type

Reference compound

Related Pathways

Apoptosis; Autophagy; Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/gemcitabine-elaidate-hydrochloride.html

Purity

99.89

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O[C@@H](C(F)(F)[C@H](N1C(N=C(C=C1)N)=O)O2)[C@H]2COC(CCCCCCC/C=C/CCCCCCCC)=O.[H]Cl

Molecular Formula

C27H44ClF2N3O5

Molecular Weight

564.11

References & Citations

[1]Bergman AM, et, al. Antiproliferative activity, mechanism of action and oral antitumor activity of CP-4126, a fatty acid derivative of gemcitabine, in in vitro and in vivo tumor models. Invest New Drugs. 2011 Jun;29 (3) :456-66.|[2]Adema AD, et, al. Cell cycle effects of fatty acid derivatives of cytarabine, CP-4055, and of gemcitabine, CP-4126, as basis for the interaction with oxaliplatin and docetaxel. Int J Oncol. 2010 Jan;36 (1) :285-94.