Vapendavir-d5

Vapendavir-d5 is the deuterium labeled Vapendavir. Vapendavir (BTA798) is a potent enteroviral capsid binder (CB) . Vapendavir (BTA798) possesses potent antiviral activity for enterovirus 71 (EV71) replication, with EC50 values of 0.5-1.4 μM in different EV71 strains[1][2].

Product Specifications

CAS Number

[2738376-73-1]

Product Name Alternative

BTA798-d5

UNSPSC

12352005

Target

Enterovirus; Isotope-Labeled Compounds

Type

Isotope-Labeled Compounds

Related Pathways

Anti-infection; Others

Field of Research

Infection

Purity

99.9

Solubility

10 mM in DMSO

Smiles

[2H]C([2H])([2H])C([2H])([2H])OC1=NOC2=CC(OCCC3CCN(C4=CC=C(N=N4)C)CC3)=CC=C12

Molecular Formula

C21H21D5N4O3

Molecular Weight

387.49

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Tijsma A, et al. The capsid binder Vapendavir and the novel protease inhibitor SG85 inhibit enterovirus 71 replication. Antimicrob Agents Chemother. 2014 Nov;58 (11) :6990-2.|[3]Sun L, et al. Antiviral Activity of Broad-Spectrum and Enterovirus-Specific Inhibitors against Clinical Isolates of Enterovirus D68. Antimicrob Agents Chemother. 2015 Dec;59 (12) :7782-5.