SCH 221510
SCH 221510 is a potent, orally active and selective NOP (nociceptin opioid receptor) agonist, with an EC50 of 12 nM and Ki of 0.3 nM. SCH 221510 shows an anxiolytic-like effect[1].
Product Specifications
CAS Number
322473-89-2
UNSPSC
12352005
Target
Opioid Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/sch-221510.html
Concentration
10mM
Purity
99.00
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O[C@](C[C@H]1CC2)(C3=CC=CC=C3)C[C@H]2N1C(C4=C(C=CC=C4)C)C5=C(C=CC=C5)C
Molecular Formula
C28H31NO
Molecular Weight
397.55
References & Citations
[1]Varty GB, et al. The anxiolytic-like effects of the novel, orally active nociceptin opioid receptor agonist 8-[bis (2-methylphenyl) methyl]-3-phenyl-8-azabicyclo[3.2.1]octan-3-ol (SCH 221510) . J Pharmacol Exp Ther. 2008 Aug;326 (2) :672-82.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
NOP Receptor/ORL1
Available Sizes
Frequently Asked Questions
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