SCH 221510

SCH 221510 is a potent, orally active and selective NOP (nociceptin opioid receptor) agonist, with an EC50 of 12 nM and Ki of 0.3 nM. SCH 221510 shows an anxiolytic-like effect[1].

Product Specifications

CAS Number

[322473-89-2]

UNSPSC

12352005

Target

Opioid Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/sch-221510.html

Concentration

10mM

Purity

99.00

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O[C@](C[C@H]1CC2)(C3=CC=CC=C3)C[C@H]2N1C(C4=C(C=CC=C4)C)C5=C(C=CC=C5)C

Molecular Formula

C28H31NO

Molecular Weight

397.55

References & Citations

[1]Varty GB, et al. The anxiolytic-like effects of the novel, orally active nociceptin opioid receptor agonist 8-[bis (2-methylphenyl) methyl]-3-phenyl-8-azabicyclo[3.2.1]octan-3-ol (SCH 221510) . J Pharmacol Exp Ther. 2008 Aug;326 (2) :672-82.