1-Oxo Ibuprofen
1-Oxo Ibuprofen (Ibuprofen EP impurity J) is a degradation product and a potential impurity in preparations of Ibuprofen. Ibuprofen is an anti-inflammatory inhibitor targeting COX-1 and COX-2 with IC50s of 13 μM and 370 μM, respectively[1][2].
Product Specifications
CAS Number
65813-55-0
Product Name Alternative
Ibuprofen EP impurity J
UNSPSC
12352005
Hazard Statement
H302
Target
Drug Metabolite
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/1-oxo-ibuprofen.html
Solubility
10 mM in DMSO
Smiles
O=C(O)C(C)C1=CC=C(C(C(C)C)=O)C=C1
Molecular Formula
C13H16O3
Molecular Weight
220.26
Precautions
P264-P270-P330-P501
References & Citations
[1]YongFang Rao, et al. Degradation of ibuprofen by a synergistic UV/Fe (III) /Oxone process. Chemical Engineering Journal. Volume 283, 1 January 2016, Pages 65-75.|[2]Noreen Y, et al. Development of a radiochemical cyclooxygenase-1 and -2 in vitro assay for identification of natural products as inhibitors of prostaglandin biosynthesis. J Nat Prod. 1998 Jan;61 (1) :2-7.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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