1-Oxo Ibuprofen

1-Oxo Ibuprofen (Ibuprofen EP impurity J) is a degradation product and a potential impurity in preparations of Ibuprofen. Ibuprofen is an anti-inflammatory inhibitor targeting COX-1 and COX-2 with IC50s of 13 μM and 370 μM, respectively[1][2].

Product Specifications

CAS Number

[65813-55-0]

Product Name Alternative

Ibuprofen EP impurity J

UNSPSC

12352005

Hazard Statement

H302

Target

Drug Metabolite

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/1-oxo-ibuprofen.html

Solubility

10 mM in DMSO

Smiles

O=C(O)C(C)C1=CC=C(C(C(C)C)=O)C=C1

Molecular Formula

C13H16O3

Molecular Weight

220.26

Precautions

P264-P270-P330-P501

References & Citations

[1]YongFang Rao, et al. Degradation of ibuprofen by a synergistic UV/Fe (III) /Oxone process. Chemical Engineering Journal. Volume 283, 1 January 2016, Pages 65-75.|[2]Noreen Y, et al. Development of a radiochemical cyclooxygenase-1 and -2 in vitro assay for identification of natural products as inhibitors of prostaglandin biosynthesis. J Nat Prod. 1998 Jan;61 (1) :2-7.