Pomalidomide 4'-alkylC4-acid
Pomalidomide 4'-alkylC4-acid (linker 16) is a E3 ligase ligand-linker conjugate. Pomalidomide 4'-alkylC4-acid contains a cereblon ligand, an alkylC4 chain, and a terminal acid. Pomalidomide 4'-alkylC4-acid can be used to couple with target protein ligands to synthesize PROTAC[1].
Product Specifications
CAS Number
[2225940-48-5]
UNSPSC
12352005
Hazard Statement
H361
Target
E3 Ligase Ligand-Linker Conjugates
Type
Reference compound
Related Pathways
PROTAC
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pomalidomide-4-alkylc4-acid.html
Purity
98.04
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
O=C(CCCCNC1=CC=CC(C(N2C3C(NC(CC3)=O)=O)=O)=C1C2=O)O
Molecular Formula
C18H19N3O6
Molecular Weight
373.36
Precautions
H361
References & Citations
[1]Michael Bruno Plewe, et al. Compounds and methods of treating cancers. China CN202080026538.3A. 2020-04-02
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Cereblon
Available Sizes
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