BS-181 (hydrochloride)

BS-181 hydrochloride is a highly selective CDK7 inhibitor with IC50 of 21 nM, and > 40-fold selective for CDK7 than CDK1, 2, 4, 5, 6, or 9.

Product Specifications

CAS Number

[1397219-81-6]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

CDK

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/BS-181-hydrochloride.html

Purity

99.93

Solubility

DMSO : ≥ 50 mg/mL|H2O : 100 mg/mL (ultrasonic)

Smiles

CC(C1=C(N=C(C=C2NCC3=CC=CC=C3)NCCCCCCN)N2N=C1)C.[H]Cl

Molecular Formula

C22H33ClN6

Molecular Weight

416.99

Precautions

H302, H315, H319, H335

References & Citations

[1]Ali S et al. The development of a selective cyclin-dependent kinase inhibitor that shows antitumor activity. Cancer Res. 2009 Aug 1;69 (15) :6208-15.|[2]Wang BY, et al. Selective CDK7 inhibition with BS-181 suppresses cell proliferation and induces cell cycle arrest and apoptosis in gastric cancer. Drug Des Devel Ther. 2016 Mar 16;10:1181-9.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

CDK1; CDK2; CDK4; CDK5; CDK6; CDK7; CDK9

Citation 01

Int J Biol Macromol. 2024 Dec 27:139117.|Universidade de Lisboa. 2021 Dec 21.|Biochem Biophys Res Commun. 2019 Jun 11;513 (4) :967-973.|Cell Rep. 2017 Dec 5;21 (10) :2796-2812.|Theranostics. 2017 Apr 20;7 (7) :1914-1927.