BS-181 (hydrochloride)
BS-181 hydrochloride is a highly selective CDK7 inhibitor with IC50 of 21 nM, and > 40-fold selective for CDK7 than CDK1, 2, 4, 5, 6, or 9.
Product Specifications
CAS Number
1397219-81-6
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
CDK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/BS-181-hydrochloride.html
Purity
99.93
Solubility
DMSO : ≥ 50 mg/mL|H2O : 100 mg/mL (ultrasonic)
Smiles
CC(C1=C(N=C(C=C2NCC3=CC=CC=C3)NCCCCCCN)N2N=C1)C.[H]Cl
Molecular Formula
C22H33ClN6
Molecular Weight
416.99
Precautions
H302, H315, H319, H335
References & Citations
[1]Ali S et al. The development of a selective cyclin-dependent kinase inhibitor that shows antitumor activity. Cancer Res. 2009 Aug 1;69 (15) :6208-15.|[2]Wang BY, et al. Selective CDK7 inhibition with BS-181 suppresses cell proliferation and induces cell cycle arrest and apoptosis in gastric cancer. Drug Des Devel Ther. 2016 Mar 16;10:1181-9.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CDK1; CDK2; CDK4; CDK5; CDK6; CDK7; CDK9
Citation 01
Int J Biol Macromol. 2024 Dec 27:139117.|Universidade de Lisboa. 2021 Dec 21.|Biochem Biophys Res Commun. 2019 Jun 11;513 (4) :967-973.|Cell Rep. 2017 Dec 5;21 (10) :2796-2812.|Theranostics. 2017 Apr 20;7 (7) :1914-1927.
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
BNC400205-500 1x 500 µL
Complement C4d (C4D205), CF640R conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
