Histatin-8

Histatin-8 is a part of the Histatin-3 central sequence and is known as hemagglutination-inhibiting peptide. Histatin-8 is a potent anti-fungal peptide. Histatin-8 shows antimicrobial activity against yeast strains. Histatin-8 can be used for oral thrush research[1][2].

OC(C=C1)=CC=C1C[C@@H](C(O)=O)NC(CNC([C@H](CCCNC(N)=N)NC([C@H](CC2=CN=CN2)NC([C@H](CO)NC([C@H](CC3=CN=CN3)NC([C@@H](NC([C@H](CCCCN)NC([C@H](CCC(O)=O)NC([C@@H](NC([C@@H](NC([C@@H](N)CCCCN)=O)CC4=CC=CC=C4)=O)CC5=CN=CN5)=O)=O)=O)CC6=CN=CN6)=O)=O)=O)=O)=O)=O

[1]Neshani A, et al. Antimicrobial peptides as a promising treatment option against Acinetobacter baumannii infections. Microb Pathog. 2020 Sep;146:104238.|[2]Matheson S M G, et al. Investigating the Effects of Hydrophobicity and Charge on the Therapeutic Ability of the Antimicrobial Histatin 8 Peptide for Potential Use in Oral Applications. International Journal of Biology, 2013.