HaloPROTAC-E

HaloPROTAC-E is a potent Halo PROTAC degrader that reversibly induces degradation of two Halo-tagged endoplasmic reticulum-localized proteins, SGK3 and VPS34, with a DC50 of 3-10 nM. HaloPROTAC-E significantly and selectively induces degradation of endogenous VPS34 complexes (VPS34, VPS15, Beclin1, and ATG14) labeled with Halo and inhibits autophagy.

Product Specifications

CAS Number

2365478-58-4

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Autophagy; PROTACs; SGK

Type

Reference compound

Related Pathways

Autophagy; Metabolic Enzyme/Protease; PROTAC

Applications

COVID-19-immunoregulation

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/haloprotac-e.html

Purity

98.76

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(C1(CC1)C#N)N[C@@H](C(C)(C)C)C(N(C[C@@H]2O)[C@@H](C2)C(NCC(C=CC(C(SC=N3)=C3C)=C4)=C4OCCOCCOCCOCCCCCCCl)=O)=O

Molecular Formula

C39H56ClN5O8S

Molecular Weight

790.41

Precautions

H315, H319, H335

References & Citations

[1]Tovell H, Testa A, Maniaci C, et al. Rapid and Reversible Knockdown of Endogenously Tagged Endosomal Proteins via an Optimized HaloPROTAC Degrader. ACS Chem Biol. 2019;14 (5) :882-892.