α-glucosidase/PTP1B-IN-1

α-glucosidase/PTP1B-IN-1 (compound 8a) is a potent α-glucosidase and PTP1B inhibitor with an IC50 value of 66.3 μM and 47.0 μM, respectively. α-glucosidase/PTP1B-IN-1 exhibits excellent activities against α-amylase with an IC50 of 30.62 μM. α-glucosidase/PTP1B-IN-1 can dock into the active pockets of α-glucosidase and PTP1B. α-glucosidase/PTP1B-IN-1 has potential to reduce the postprandial blood glucose and is used for Type 2 diabetes mellitus[1].

Product Specifications

UNSPSC

12352005

Target

Amylases; Glycosidase; Phosphatase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/α-glucosidase-ptp1b-in-1.html

Smiles

ClC1=CC(Cl)=C(/C=C/C(OCCOC2=CC(C)=C3C(OC(C(C)=C3C)=O)=C2)=O)C=C1

Molecular Formula

C23H20Cl2O5

Molecular Weight

447.31

References & Citations

[1]Wei Yang, et al. Design, synthesis and enzymatic inhibition evaluation of novel 4-hydroxy Pd-C-III derivatives as α-glucosidase and PTP1B dual-target inhibitors. Eur J Med Chem. 2024 Dec 15:280:116938.