α-glucosidase/PTP1B-IN-1
Product Specifications
UNSPSC Description
α-glucosidase/PTP1B-IN-1 (compound 8a) is a potent α-glucosidase and PTP1B inhibitor with an IC50 value of 66.3 μM and 47.0 μM, respectively. α-glucosidase/PTP1B-IN-1 exhibits excellent activities against α-amylase with an IC50 of 30.62 μM. α-glucosidase/PTP1B-IN-1 can dock into the active pockets of α-glucosidase and PTP1B. α-glucosidase/PTP1B-IN-1 has potential to reduce the postprandial blood glucose and is used for Type 2 diabetes mellitus[1].
Target Antigen
Amylases; Glycosidase; Phosphatase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/α-glucosidase-ptp1b-in-1.html
Smiles
ClC1=CC(Cl)=C(/C=C/C(OCCOC2=CC(C)=C3C(OC(C(C)=C3C)=O)=C2)=O)C=C1
Molecular Weight
447.31
References & Citations
[1]Wei Yang, et al. Design, synthesis and enzymatic inhibition evaluation of novel 4-hydroxy Pd-C-Ⅲ derivatives as α-glucosidase and PTP1B dual-target inhibitors. Eur J Med Chem. 2024 Dec 15:280:116938.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-168185/α-glucosidase-PTP1B-IN-1-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-168185/
Clinical Information
No Development Reported
Curated Selection
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