HSMG-1 inhibitor 11j
HSMG-1 inhibitor 11j, a pyrimidine derivative, is a potent and selective inhibitor of hSMG-1, with an IC50 of 0.11 nM. hSMG-1 inhibitor 11j exhibits >455-fold selectivity for hSMG-1 over mTOR (IC50=50 nM), PI3Kα/γ (IC50=92/60 nM) and CDK1/CDK2 (IC50=32/7.1 μM) . hSMG-1 inhibitor 11j can be used for the research of cancer[1].
Product Specifications
CAS Number
[1402452-15-6]
UNSPSC
12352005
Target
CDK; GSK-3; mTOR; PI3K
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; PI3K/Akt/mTOR; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/hsmg-1-inhibitor-11j.html
Purity
99.82
Solubility
DMSO : 80 mg/mL (ultrasonic)
Smiles
O=S(C1=CC(NC2=NC=CC(C3=CC(C4=CC=C(NC(NC)=O)C=C4)=NC=C3)=N2)=CC=C1Cl)(N(CC)CC)=O
Molecular Formula
C27H28ClN7O3S
Molecular Weight
566.07
References & Citations
[1]Gopalsamy A, et, al. Identification of pyrimidine derivatives as hSMG-1 inhibitors. Bioorg Med Chem Lett. 2012 Nov 1;22 (21) :6636-41.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CDK1; CDK2; mTOR; PI3Kα; PI3Kγ
Available Sizes
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