Nampt activator-3
NAMPT activator-3, a NAT derivative, is a NAMPT activator with an EC50 of 2.6 μM and a KD of 132 nM. NAMPT activator-3 effectively protects cultured cells from FK866 (HY-50876) -mediated toxicity. NAMPT activator-3 exhibits strong neuroprotective efficacy in a chemotherapy-induced peripheral neuropathy (CIPN) mouse model without any overt toxicity[1].
Product Specifications
CAS Number
[2790481-63-7]
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
NAMPT
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/nampt-activator-3.html
Purity
99.71
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
N#CC1=CC=CC(C(C)(C)C)=C1OCC(NC2=CC=C(C=C2)O)=O
Molecular Formula
C19H20N2O3
Molecular Weight
324.37
Precautions
H302, H315, H319
References & Citations
[1]Leibo Wang, et al. Optimization of NAMPT activators to achieve in vivo neuroprotective efficacy. Eur J Med Chem. 2022 Jun 5;236:114260.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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