Pyridinium bisretinoid A2E-d4 (TFA)

Pyridinium bisretinoid A2E-d4 TFA is the deuterium-labeled Pyridinium bisretinoid A2E (HY-134928) . Pyridinium bisretinoid A2E (A2E) is an initiator of blue-light-induced apoptosis. Photoactivation of Pyridinium bisretinoid A2E mediates autophagy and the production of reactive oxygen species[1][2][3][4].

Product Specifications

Product Name Alternative

A2E-d4 (TFA)

UNSPSC

12352005

Target

Isotope-Labeled Compounds

Type

Isotope-Labeled Compounds

Related Pathways

Others

Applications

Cancer-programmed cell death

Field of Research

Cancer

Purity

90.0

Solubility

DMSO : 4 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

OC([2H])([2H])C([2H])([2H])[N+]1=CC=C(/C=C/C=C(C)/C=C/C2=C(C)CCCC2(C)C)C=C1/C=C(C)/C=C/C=C(C)/C=C/C3=C(C)CCCC3(C)C.O=C([O-])C(F)(F)F

Molecular Formula

C44H54D4F3NO3

Molecular Weight

709.96

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216. |[2]Jeong SY, et al. Photoactivation of N-retinylidene-N-retinylethanolamine compromises autophagy in retinal pigmented epithelial cells. Food Chem Toxicol. 2019 Sep;131:110555. |[3]S. Ben-Shabat, et al; Elucidating the Role of Pyridinium bis-Retinoid (A2E) in Retinal Pigment Epithelium (RPE) Cell Damages. Invest. Ophthalmol. Vis. Sci. 2007;48 (13) :2201. |[4]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-218.