N, N'-Methylenebisacrylamide

N, N'-Methylenebisacrylamide (Bisacrylamide) is an orally active acrylamide dimer and crosslinker. N, N'-Methylenebisacrylamide increases CYP2E1, P53, cleaved caspase-3. N, N'-Methylenebisacrylamide promotes hepatic cancer. N, N'-Methylenebisacrylamide changes sperm abnormality rate and sperm count. N, N'-Methylenebisacrylamide decreases the number of various cells in the blood as well as induces liver and testicular damage. N, N'-Methylenebisacrylamide is used to prepare polyacrylamide gel[1][2][3][4][5][6][7].

Product Specifications

CAS Number

[110-26-9]

Product Name Alternative

Bisacrylamide; MBA; Methylenebisacrylamide; N, N-Methylenebisacrylamide

UNSPSC

12352200

Hazard Statement

H301, H312, H340, H350, H361, H372

Target

Biochemical Assay Reagents; Caspase; MDM-2/p53

Type

Biochemical Assay Reagents

Related Pathways

Apoptosis; Others

Field of Research

Cancer; Endocrinology; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/n-n-methylenebisacrylamide.html

Purity

99.98

Solubility

DMSO : 25 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

C=CC(NCNC(C=C)=O)=O

Molecular Formula

C7H10N2O2

Molecular Weight

154.17

Precautions

H301, H312, H340, H350, H361, H372

References & Citations

[5]Atia MM, et al. Rehabilitation of N, N'-methylenebisacrylamide-induced DNA destruction in the testis of adult rats by adipose-derived mesenchymal stem cells and conditional medium. Heliyon. 2024 Nov 14;10 (23) :e40380.|[6]Sakamoto J, et al. Effects of N, N'-methylene-bis-acrylamide (MBA) on mouse germ cells--sperm count and morphology, and testicular pathology. Arch Toxicol. 1988 Aug;62 (1) :54-9. |[7]Hashimoto K, et al. Anemia and porphyria caused by N, N'-methylene-bis-acrylamide (MBA) in mice and rats. Arch Toxicol. 1982 May;50 (1) :47-55.|[1]Atia MM, et al. Nanocurcumin and curcumin prevent N, N'-methylenebisacrylamide-induced liver damage and promotion of hepatic cancer cell growth. Sci Rep. 2022 May 18;12 (1) :8319.|[2]George JD, et al. Evaluation of the developmental toxicity of methacrylamide and N, N'-methylenebisacrylamide in Swiss mice. Toxicol Sci. 1998 Nov;46 (1) :124-33.|[3]de Souza Pereira R. Comparison of biochemical effects produced by calcium ions and by monomers of polyacrylamide (acrylamide and bisacrylamide) on strains of Saccharomyces cerevisiae used for production of chiral synthons. Mol Cell Biochem. 1998 Jan;178 (1-2) :33-40. |[4]Atia M M, et al. The immunomodulatory role of curcumin and its nanoparticles in mice testis exposed to N, N'-methylenebisacrylamide. Egyptian Academic Journal of Biological Sciences, B. Zoology, 2022, 14 (1) : 39-54.