[Pyr1]-Apelin-13 (Human)

<strong>[Pyr1]-Apelin-13 (Human)</strong> <strong>Catalog number:</strong> MDP0730 <strong>CAS Number: </strong>N/A <strong>Sequence: </strong>Pyr-Arg-Pro-Arg-Leu-Ser-His-Lys-Gly-Pro-Met-Pro-Phe <strong>Amount:</strong> 500 ug <strong>Molecular Weight:</strong> 1533.6 g/mol <strong>Supplied as:</strong> Powder <strong>Applications:</strong> molecular tool for various biochemical applications <strong>Storage:</strong> -20 °C <strong>WARNING:</strong> For in vitro Research Use Only. NOT for use on humans or animals. <strong>Grade:</strong> Biotechnology grade. All products are highly pure. <strong>References:</strong> 1: Maguire JJ, Kleinz MJ, Pitkin SL, Davenport AP. [Pyr1]apelin-13 identified as the predominant apelin isoform in the human heart: vasoactive mechanisms and inotropic action in disease Hypertension. 2009 Sep;54(3):598-604. 2: Sahinturk S, Demirel S, Ozyener F, Isbil N. [Pyr1]apelin-13 relaxes the rat thoracic aorta via APJ, NO, AMPK, and potassium channels Gen Physiol Biophys. 2021 Sep;40(5):427-434. 3: Zhen EY, Higgs RE, Gutierrez JA. Pyroglutamyl apelin-13 identified as the major apelin isoform in human plasma Anal Biochem. 2013 Nov 1;442(1):1-9. 4: De Hert E, Bracke A, Pintelon I, Janssens E, Lambeir AM, Van Der Veken P, De Meester I. Prolyl Carboxypeptidase Mediates the C-Terminal Cleavage of (Pyr)-Apelin-13 in Human Umbilical Vein and Aortic Endothelial Cells Int J Mol Sci. 2021 Jun 22;22(13):6698. 5: Yang P, Kuc RE, Brame AL, Dyson A, Singer M, Glen RC, Cheriyan J, Wilkinson IB, Davenport AP, Maguire JJ. [Pyr(1)]Apelin-13((1-12)) Is a Biologically Active ACE2 Metabolite of the Endogenous Cardiovascular Peptide [Pyr(1)]Apelin-13 Front Neurosci. 2017 Feb 28;11:92. 6: Yamaleyeva LM, Chappell MC, Brosnihan KB, Anton L, Caudell DL, Shi S, McGee C, Pirro N, Gallagher PE, Taylor RN, Merrill DC, Mertz HL. Downregulation of apelin in the human placental chorionic villi from preeclamptic pregnancies Am J Physiol Endocrinol Metab. 2015 Nov 15;309(10):E852-60. 7: Park J, Park MY, Kim Y, Jun Y, Lee U, Oh CM. Apelin as a new therapeutic target for COVID-19 treatment QJM. 2023 Mar 27;116(3):197-204. 8: Yamaleyeva LM, Brosnihan KB, Elsangeedy E, McGee C, Shi S, Caudell D, Miller C, Varagic J, Bader M, Dechend R, Shaltout HA. Systemic Outcomes of (Pyr(1))-Apelin-13 Infusion at Mid-Late Pregnancy in a Rat Model with Preeclamptic Features Sci Rep. 2019 Jun 12;9(1):8579. 9: Nyimanu D, Kay RG, Sulentic P, Kuc RE, Ambery P, Jermutus L, Reimann F, Gribble FM, Cheriyan J, Maguire JJ, Davenport AP. Development and validation of an LC-MS/MS method for detection and quantification of in vivo derived metabolites of [Pyr(1)]apelin-13 in humans Sci Rep. 2019 Dec 27;9(1):19934. <a href="https://pubmed.ncbi.nlm.nih.gov/35578855">10: Sahinturk S, Demirel S, Isbil N, Ozyener F. Potassium Channels Contributes to Apelin-induced Vasodilation in Rat Thoracic Aorta Protein Pept Lett. 2022;29(6):538-549. </a> <br><strong>Products Related to [Pyr1]-Apelin-13 (Human) can be found at</strong> <a href="https://moleculardepot.com/product-category/Peptides/"> Peptides</a>