Coumarin 106

Coumarin 106 (Coumarin 478) is a dipolar laser dye. Coumarin 106 is an inhibitor of AChE and BChE. Coumarin 106 displays mixed-type AChE inhibition with a pIC50=4.97 and Ki=2.36 μM. Coumarin 106 inhibits BChE with slightly lower potency (pIC50=4.56) [1][2].

Product Specifications

CAS Number

[41175-45-5]

Product Name Alternative

Coumarin 478

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Cholinesterase (ChE)

Type

Reference compound

Related Pathways

Neuronal Signaling

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/coumarin-106.html

Purity

99.76

Solubility

DMSO : ≥ 25 mg/mL

Smiles

O=C1OC2=C(C=C3C4=C2CCCN4CCC3)C5=C1CCC5

Molecular Formula

C18H19NO2

Molecular Weight

281.35

Precautions

H302, H315, H319, H335

References & Citations

[1]Patil SK, et al. Determination of ground and excited state dipole moments of dipolar laser dyes by solvatochromic shift method. Spectrochim Acta A Mol Biomol Spectrosc. 2014 Apr 5;123:117-26. |[2]Fallarero A, et al. Inhibition of acetylcholinesterase by coumarins: the case of coumarin 106. Pharmacol Res. 2008 Sep-Oct;58 (3-4) :215-21.