Ziconotide (acetate)

Ziconotide acetate (SNX-111 acetate), a peptide, is a potent and selective block of N-type calcium channels antagonist. Ziconotide acetate reduces synaptic transmission, and can be used for chronic pain research[1].

Product Specifications

CAS Number

[914454-03-8]

Product Name Alternative

SNX-111 (acetate)

UNSPSC

12352209

Target

Calcium Channel

Type

Peptides

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Cardiovascular Disease; Cancer

Assay Protocol

https://www.medchemexpress.com/ziconotide-acetate.html

Purity

99.29

Solubility

DMSO : 25 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic)

Smiles

O=C(N[C@H](C(N[C@]1([H])C(N[C@]2([H])C(N[C@@](C(NCC(N[C@@](C(N[C@@](C(N[C@](CCCNC(N)=N)([H])C(N[C@@H](CO)C(NCC(N[C@@H](CCCCN)C(N[C@H](C(N)=O)CSSC1)=O)=O)=O)=O)=O)([H])CSSC[C@@](NC([C@](NC([C@@H](NC(CNC([C@H](CCCCN)NC(CNC([C@H](CCCCN)NC([C@@H](N)CSSC2)=O)=O)=O)=O)=O)C)=O)([H])CCCCN)=O)([H])C(N[C@@H](CO)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC(C)C)C(N[C@@H](CCSC)C3=O)=O)=O)=O)=O)=O)([H])CO)=O)=O)([H])[C@H](O)C)=O)=O)=O)CC(O)=O)[C@](N3)([H])CC4=CC=C(O)C=C4.CC(O)=O.[x]

Molecular Formula

C102H172N36O32S7.xC2H4O2

Molecular Weight

2639.13 (free base)

References & Citations

[1]Joseph G McGivern, et al. Ziconotide: a review of its pharmacology and use in the treatment of pain. Neuropsychiatr Dis Treat. 2007 Feb;3 (1) :69-85.|[2]Rodrigo B M Silva, et al. Beneficial Effects of the Calcium Channel Blocker CTK 01512-2 in a Mouse Model of Multiple Sclerosis. Mol Neurobiol. 2018 Dec;55 (12) :9307-9327.