2'-Deoxyadenosine-5'-triphosphate (trisodium)

2'-Deoxyadenosine-5'-triphosphate (dATP) trisodium is a nucleotide used in cells for DNA synthesis (or replication), as a substrate of DNA polymerase. 2'-Deoxyadenosine-5'-triphosphate is promising for research of genetic immunodeficiency diseases adenosine deaminase deficiency and purine nucleotide phosphorylase deficiency [1][2][3][4].

Product Specifications

CAS Number

[54680-12-5]

Product Name Alternative

DATP (trisodium)

UNSPSC

12352200

Hazard Statement

H302, H315, H319, H335

Target

DNA/RNA Synthesis; Endogenous Metabolite

Type

Biochemical Assay Reagents

Related Pathways

Cell Cycle/DNA Damage; Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/2-deoxyadenosine-5-triphosphate-trisodium.html

Purity

98.0

Solubility

H2O : 250 mg/mL (ultrasonic)

Smiles

O[C@H]([C@H](O1)CO[P](O[P](O[P](O)(O[Na])=O)(O[Na])=O)(O[Na])=O)C[C@@H]1N2C3=NC=NC(N)=C3N=C2

Molecular Formula

C10H13N5Na3O12P3

Molecular Weight

557.13

Precautions

H302, H315, H319, H335

References & Citations

[1]P J Romaniuk, A study of the mechanism of T4 DNA polymerase with diastereomeric phosphorothioate analogues of deoxyadenosine triphosphate. J Biol Chem. 1982 Jul 10;257 (13) :7684-8.|[2]Yang JC, Cortopassi GA. dATP causes specific release of cytochrome C from mitochondria. Biochem Biophys Res Commun. 1998 Sep 18;250 (2) :454-7.|[3]Katona K, et al. Deoxy-adenosine-monophosphate (dAMP) di-n-butylester induces apoptosis by increasing the dATP level in HL-60 cells. Cancer Lett. 2006 Apr 28;235 (2) :281-90.|[4]Xi C, Wu J. dATP/ATP, a multifunctional nucleotide, stimulates bacterial cell lysis, extracellular DNA release and biofilm development. PLoS One. 2010 Oct 14;5 (10) :e13355.