RK-20448

RK-20448 is an ATP-competitive inhibitor of Lck, Src, KDR/VEGF2R and Tie-2 with IC50 values of 0.24, 1.19, 10.74 and 5.85 µM, respectively. RK-20448 also inhibits BLK, Csk, Fyn and Lyn with IC50 values of 0.37, 4.27, 2.03 and 0.43 µM, respectively. RK-20448 is the cis isomer of A-419259 (HY-15764) [1][2].

Product Specifications

CAS Number

[479501-40-1]

Product Name Alternative

YH439,Ticalopride,(±)-Norcisapride; rel-Ticalopride

UNSPSC

12352005

Target

Src; Tie; VEGFR

Type

Reference compound

Related Pathways

Protein Tyrosine Kinase/RTK

Field of Research

Cancer; Infection

Assay Protocol

https://www.medchemexpress.com/rk-20448.html

Purity

99.38

Solubility

DMSO : 25 mg/mL (ultrasonic;warming;heat to 60°C)

Smiles

NC1=C(C2=NC=N1)C(C3=CC=C(C=C3)OC4=CC=CC=C4)=CN2[C@H]5CC[C@H](CC5)N6CCN(CC6)C

Molecular Formula

C29H34N6O

Molecular Weight

482.62

References & Citations

[1]Saito Y, et al. A pyrrolo-pyrimidine derivative targets human primary AML stem cells in vivo. Sci Transl Med. 2013 Apr 17;5 (181) :181ra52.|[2]Almoyad MAA, et al. Hematopoietic cell kinase as a nexus for drug repurposing: implications for cancer and HIV therapy. J Biomol Struct Dyn. 2024 Mar 26:1-11.