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4'-Hydroxy diclofenac

4'-Hydroxy diclofenac is an orally active metabolite of Diclofenac by cytochrome P450 2C9 (CYP2C9). 4'-Hydroxy diclofenac has anti-inflammatory and analgesic properties[1][2].

Product Specifications

CAS Number

64118-84-9

UNSPSC

12352005

Hazard Statement

H301, H318

Target

Drug Metabolite

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/4-hydroxy-diclofenac.html

Concentration

10mM

Purity

99.70

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(O)CC1=CC=CC=C1NC2=C(Cl)C=C(O)C=C2Cl

Molecular Formula

C14H11Cl2NO3

Molecular Weight

312.15

Precautions

H301, H318

References & Citations

[1]J Shimamoto, et al. Lack of Differences in Diclofenac (A Substrate for CYP2C9) Pharmacokinetics in Healthy Volunteers With Respect to the Single CYP2C9*3 Allele. Eur J Clin Pharmacol. 2000 Apr;56 (1) :65-8.|[2]Hidetaka Kamimura, et al. Formation of the Accumulative Human Metabolite and Human-Specific Glutathione Conjugate of Diclofenac in TK-NOG Chimeric Mice With Humanized Livers. Drug Metab Dispos. 2015 Mar;43 (3) :309-16.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C (Powder, protect from light, stored under nitrogen)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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