Dehydrocostus Lactone (Standard)

Dehydrocostus Lactone (Standard) ((-) -Dehydrocostus lactone (Standard) ) is the analytical standard of Dehydrocostus Lactone (HY-N0591) . This product is intended for research and analytical applications. Dehydrocostus Lactone is a natural sesquiterpene that can be isolated from Saussurea lappa. Dehydrocostus Lactone has multiple activities such as anti-inflammatory, antibacterial, anti-tumor, and immunomodulatory effects. Dehydrocostus Lactone has an MIC of 2 µg/mL against Mycobacterium tuberculosis. Dehydrocostus Lactone can also inhibit the killing activity of cytotoxic T lymphocytes and induce apoptosis in tumor cells.

Product Specifications

CAS Number

[477-43-0]

Product Name Alternative

(-) -Dehydrocostus lactone (Standard) ; Epiligulyl oxide (Standard)

UNSPSC

12352005

Target

Akt; Apoptosis; Bacterial; Caspase; Interleukin Related; MAPKAPK2 (MK2) ; NF-κB; NO Synthase; p38 MAPK; Reference Standards

Type

Reference Standards

Related Pathways

Anti-infection; Apoptosis; Immunology/Inflammation; MAPK/ERK Pathway; NF-κB; Others; PI3K/Akt/mTOR

Field of Research

Cancer; Infection; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/dehydrocostus-lactone-standard.html

Smiles

O=C(O[C@@]([C@@]1([H])C(CC[C@@]21[H])=C)([H])[C@@]3([H])CCC2=C)C3=C

Molecular Formula

C15H18O2

Molecular Weight

230.30

References & Citations

[1]Eun Ji Kim, et al. Apoptosis of DU145 human prostate cancer cells induced by dehydrocostus lactone isolated from the root of Saussurea lappa. Food and Chemical Toxicology Volume 46, Issue 12, December 2008, Pages 3651–3658|[2]Lee HJ, et al. A sesquiterpene, dehydrocostus lactone, inhibits the expression of inducible nitric oxide synthase and TNF-alpha in LPS-activated macrophages. Planta Med. 1999 Mar;65 (2) :104-8.|[3]Taniguchi M, et al. COSTUNOLIDE AND DEHYDROCOSTUS LACTONE AS INHIBITORS OF KILLING FUNCTION OF CYTOTOXIC T LYMPHOCYTES. Bioscience, Biotechnology, and Biochemistry, 1995, 59 (11) : 2064-2067|[4]Nie Y, Wang Z, Chai G, et al. Dehydrocostus Lactone Suppresses LPS-induced Acute Lung Injury and Macrophage Activation through NF-κB Signaling Pathway Mediated by p38 MAPK and Akt. Molecules. 2019;24 (8) :1510.