RET-IN-23
RET-IN-23 (compound 17) is a potent and orally active RET inhibitor with IC50 values of 1.32, 2.50, 6.54, 1.03, 1.47 nM for RET-WT, RET-CCDC6, RET-V804L, RET-V804M, RET-M918T, respectively. RET-IN-23 shows anti-tumor activity[1].
Product Specifications
CAS Number
[2479961-46-9]
UNSPSC
12352005
Target
RET
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ret-in-23.html
Solubility
10 mM in DMSO
Smiles
CC1=CC(NC2=NNC(C)=C2)=NC(C3=CC=C(N4CC(C5)N(CC6=CC=C(N7C=C(F)C=N7)N=C6)C5C4)N=C3)=N1
Molecular Formula
C28H28FN11
Molecular Weight
537.59
References & Citations
[1]ZhongHui Chen, et al. Heterocyclic compound, pharmaceutical composition comprising same, preparation method therefor, and use thereof. WO2020168939A1.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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