RET-IN-23
Product Specifications
UNSPSC Description
RET-IN-23 (compound 17) is a potent and orally active RET inhibitor with IC50 values of 1.32, 2.50, 6.54, 1.03, 1.47 nM for RET-WT, RET-CCDC6, RET-V804L, RET-V804M, RET-M918T, respectively. RET-IN-23 shows anti-tumor activity[1].
Target Antigen
RET
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ret-in-23.html
Solubility
10 mM in DMSO
Smiles
CC1=CC(NC2=NNC(C)=C2)=NC(C3=CC=C(N4CC(C5)N(CC6=CC=C(N7C=C(F)C=N7)N=C6)C5C4)N=C3)=N1
Molecular Weight
537.59
References & Citations
[1]ZhongHui Chen, et al. Heterocyclic compound, pharmaceutical composition comprising same, preparation method therefor, and use thereof. WO2020168939A1.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-153676/RET-IN-23-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-153676/
Clinical Information
No Development Reported
CAS Number
2479961-46-9
Available Sizes
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
