RET-IN-23

RET-IN-23 (compound 17) is a potent and orally active RET inhibitor with IC50 values of 1.32, 2.50, 6.54, 1.03, 1.47 nM for RET-WT, RET-CCDC6, RET-V804L, RET-V804M, RET-M918T, respectively. RET-IN-23 shows anti-tumor activity[1].

Product Specifications

CAS Number

[2479961-46-9]

UNSPSC

12352005

Target

RET

Type

Reference compound

Related Pathways

Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ret-in-23.html

Solubility

10 mM in DMSO

Smiles

CC1=CC(NC2=NNC(C)=C2)=NC(C3=CC=C(N4CC(C5)N(CC6=CC=C(N7C=C(F)C=N7)N=C6)C5C4)N=C3)=N1

Molecular Formula

C28H28FN11

Molecular Weight

537.59

References & Citations

[1]ZhongHui Chen, et al. Heterocyclic compound, pharmaceutical composition comprising same, preparation method therefor, and use thereof. WO2020168939A1.