HMGB1-IN-1
Product Specifications
UNSPSC Description
HMGB1-IN-1 (compound 6) displays strong NO inhibitory effect in RAW264.7 cells with IC50 value of 15.9 ± 0.6 μM. HMGB1-IN-1 inhibit the HMGB1/NF-κB/NLRP3 pathway. HMGB1-IN-1 shows good anti-inflammatory activity and good anti-sepsis effects in kidney injury[1].
Target Antigen
Interleukin Related; NOD-like Receptor (NLR); TNF Receptor
Type
Reference compound
Related Pathways
Apoptosis;Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/hmgb1-in-1.html
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
O=C(C=C1[C@@]2([C@@](CC[C@@]31C)(CC[C@@](C)(C2)C(OCC4=CN([C@@H]5O[C@H](COC(C)=O)[C@H](OC(C)=O)[C@H](OC(C)=O)[C@H]5OC(C)=O)N=N4)=O)C)[H])[C@@]6([C@@](CC[C@@H](C7(C)C)OC(/C=C/C8=CC=C(OC)C=C8)=O)(C7CC[C@@]36C)C)[H]
Molecular Weight
1042.22
References & Citations
[1]Qiang X, et al. Synthesis of glycyrrhizin analogues as HMGB1 inhibitors and their activity against sepsis in acute kidney injury. Eur J Med Chem. 2023 Nov 5;259:115696.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-155751/HMGB1-IN-1-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-155751/HMGB1-IN-1-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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